In order to be used in applications, isolated skyrmions must be thermally stable at the scale of years. In this work, their stability is studied through two main approaches: the Kramers' method in the form of Langer's theory, and the forward flux sampling method. Good agreement is found between the two methods. We find that small skyrmions possess low internal energy barriers, but are stabilized by a large activation entropy. This is a direct consequence of the existence of stable modes of deformation of the skyrmion. Additionally, frustrated exchange that arises at some transition metal interfaces leads to new collapse paths in the form of the partial nucleation of the corresponding antiparticle, as merons and antimerons.